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Long-term survival of monkey with transplanted pig kidney offers hope in alternative organ search: Scientists_我的网站

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一 | Harvard-affiliated scientists say they have been able to keep a monkey alive for two years with a genetically engineered pig kidney. Although preliminary, transplant experts say this research is an important milestone in the search for an alternative source of organs.Scientists are hopeful that one day, genetically modified organs grown in pigs may be able to significantly extend the life of people with end-stage organ failure.In recent months, other high-profile research teams at New York University and the University of Alabama at Birmingham announced successful transplants of genetically modified pig-kidneys into brain dead human donors. But those experiments ended after a few weeks."Duration of survival has been an Achilles heel of genetically modified pig organs to date due to a combination of rejection and opportunistic infections," said Dr. Peter Chin-Hong, director of the transplant infectious disease program at University of California, San Francisco.This new research, published in Nature, represents the longest period of time that scientists have been able to keep a non-human primate research animal alive."This proof-of-concept study provides real hope that transplantation of porcine [pig] donor kidneys into humans is very much on the horizon," Chin-Hong said.Still, experts cautioned that this new research was preliminary, and the idea of pig-grown organs is likely several years away from becoming a reality."If ultimately proved successful in human organ recipients - which is still years away at this point - this could be one of the key advances needed to make xenotransplantation a reality in clinical practice," said Dr. Josh Levitsky, president of the American Society of Transplantation.The new research was led by eGenesis, a company co-founded by Harvard geneticist George Church. In a press release, scientists at eGenesis said the new research will help lay the groundwork for formal clinical trials.In prepared remarks, eGenesis CEO Michael Curtis, PhD, said the company is focused on "improving long-term survival for transplant recipients from months to years."Eventually, the hope is that transplant doctors will be able to use genetically modified pig organs instead of solely relying on deceased human organ donors."Among all solid organs transplanted, kidneys are most sought after, expected to increase in demand further, and there is a significant shortfall of organs leading to premature deaths," Chin-Hong said.Every day, 17 people die waiting on the organ transplant list, according to the Health Resources & Services Administration. There are currently more than 100,000 people waiting on the national transplant list and a new person is added to the list every 10 minutes.。 10月8日，记者从辽宁出入境边防检查总站获悉，国庆假期，辽宁口岸累计查验出入境人员近6万人次，同比增长32%，交通运输工具1400余艘（架、辆）次，同比增长2倍。　　据了解，今年以来，随着出入境各项免签政策红利的释放以及辽宁文旅产业的火爆，辽宁口岸迎来出入境旅游热，国庆期间游客较去年同期增长29%，其中，来自韩国、日本、俄罗斯、新加坡等国的游客较多。

二 | 　　为保障国庆假期口岸高效顺畅通关，辽宁出入境边防检查总站提前发布“两公布一提示”，预测客流高峰，提示旅客通关注意事项。边检机关在客流密集时间段，增配执勤警力，动态优化查验通道比例，加强出入境旅客分流引导。增加中国公民专用通道，确保中国公民通关候检时间不超过30分钟。同时，增设外语通关指引标识，组建多语种志愿服务队伍，投放“外国人入境登记卡自助填报终端”，为外籍旅客提供通关便利。　　在货运方面，辽宁作为东北地区对外开放的重要门户，国庆假期出入境交通工具持续增多。辽宁出入境边防检查总站推出“边检即时通”一键通关小程序，“潮前办”“绿色直通车”等大型船舶精准通关方式，大幅缩短通关时间，出入境交通工具创近年来新高。责任编辑：李丹。

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